Nature Technology Corporation is now part of Aldevron. NTC Technologies product information is moving on December 30, 2022.
Biologics by Design
Biologics by Design
DNA Plasmid Technology at its BEST
Revolutionizing Manufacturing. Advancing Medicine. NTC proprietary Nanoplasmid™ vector and HyperGRO™ manufacturing platforms offer a wide range of applications that improve the safety and performance of plasmids and biologics.
The Nanoplasmid™ vector technology provides significant advantages over other earlier generation plasmid DNA backbones and selection methods. The Nanoplasmid™ vector can be utilized in both direct and indirect applications. Combining advantages of antibiotic-free selection and high transgene expression, the vector is suited for a variety of gene therapy applications
Increase your YIELD
Increase your YIELD
Discover why HyperGRO™ is the ideal fermentation process for vaccines and gene therapeutics
Yield Comparison, typical vs HyperGRO™
Yields can reach up to 3,500 mg/L
The HyperGRO™ fermentation unit operation is a plug and play platform. Simply swap into existing manufacturing processes to improve manufacturing yield and quality.
High plasmid yields
Yields of 1 g/L common with typical pUC plasmids, up to 3.5 g pDNA/L with NTC vectorsHigh specific plasmid yields
Up to 25 mg/L/OD600, 50 mg pDNA/g DCW (5% of total)High productivity: up to 50 mg/L/hour
Low metabolic burden process; improved production with unstable & toxic plasmids
- REVIVER™ host strain for AAV ITR vector stabilization and high yield fermentation
- Compatible with NTC’s antibiotic-free sucrose selection and Nanoplasmid™ vectors
Scaled to 100 L & 320 L GMP production at >1 g/L
