Biologics by Design
Biologics by Design
DNA Plasmid Technology at its BEST
Revolutionizing Manufacturing. Advancing Medicine. NTC proprietary Nanoplasmid™ vector and HyperGRO™ manufacturing platforms offer a wide range of applications that improve the safety and performance of plasmids and biologics.
The Nanoplasmid™ vector technology provides significant advantages over other earlier generation plasmid DNA backbones and selection methods. The Nanoplasmid™ vector can be utilized in both direct and indirect applications. Combining advantages of antibiotic-free selection and high transgene expression, the vector is suited for a variety of gene therapy applications
Increase your YIELD
Increase your YIELD
Discover why HyperGRO™ is the ideal fermentation process for vaccines and gene therapeutics
Yield Comparison, typical vs HyperGRO™
Yields can reach up to 3,500 mg/L
The HyperGRO™ fermentation unit operation is a plug and play platform. Simply swap into existing manufacturing processes to improve manufacturing yield and quality.
High plasmid yields
Yields of 1 g/L common with typical pUC plasmids, up to 3.5 g pDNA/L with NTC vectorsHigh specific plasmid yields
Up to 25 mg/L/OD600, 50 mg pDNA/g DCW (5% of total)High productivity: up to 50 mg/L/hour
Low metabolic burden process; improved production with unstable & toxic plasmids
- REVIVER™ host strain for AAV ITR vector stabilization and high yield fermentation
- Compatible with NTC’s antibiotic-free sucrose selection and Nanoplasmid™ vectors
Scaled to 100 L & 320 L GMP production at >1 g/L
REVIVER™
REVIVER™ is a more stable, higher yielding E. coli host for AAV ITR plasmids
Highly Stable
