The Problem

  • Widespread use of DNA vaccines has been hampered logistically by the to use electroporation for effective delivery
  • In addition, current delivery methods requiring specialized training, advanced technology and access to a sustainable power sources pose significant challenges in remote areas or when enacting a ring vaccination strategy in an outbreak setting
  • A simpler approach for DNA vaccine delivery that can provide protective efficacy comparable to EP could be advantageous for the broader applicability of this platform.

The Solution: Nanoplasmid™

  • Venezuelan equine encephalitis virus (VEEV) and Ebola virus (EBOV) DNA vaccines constructed using minimalized Nanoplasmid expression vectors increased antibody responsesfurther enhanced innate immune agonist genes, and increased protection against aerosol VEEV challenge
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