Increased yield, quality and productivity–HyperGRO makes it possible.

Nature Technology’s proprietary HyperGRO plasmid DNA manufacturing platform is an advanced, fed-batch, nutrient-limited process that utilizes a temperature shift to reach record high yields of up to 3.5 g/L. The HyperGRO platform host strains and process show significant improvement on vector yield, quality, and transgene expression. Nanoplasmid and RNA-OUT specific strains improve replication of DNA vectors and provide scalable high yield manufacturing using HyperGRO. The REVIVER strain for stable production of ITR and large palindrome-containing plasmids provides stabilization and high yield manufacturing benefits for AAV ITR vectors. The HyperGRO platform has been utilized by multiple CMOs and pharmaceutical companies for clinical and commercial production.

Widely applicable

Small Scale
Large Scale
Research Grade

Production of highly-purified research-grade plasmid DNA at NTC’s Lincoln, Nebraska, USA plant range from 1mg to multi-gram scale, and production capabilities for GMP-grade DNA at NTC’s CMO partners range from a hundred milligrams upward.

Our low metabolic-burden cell banking and fed-batch process produces higher specific and volumetric yield than typical batch and fed-batch processes: Up to 3.5 g/L plasmid yield with optimized NTC vectors.

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