The Nanoplasmid (RNA-OUT selectable marker plus R6K origin) replaces antibiotics with sucrose selection, and replaces the promiscuous pUC origin with the host-restricted R6K one. It is regulatory compliant and smaller in size (<500 bp) than conventional marker/ORIs.
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In the DNA manufacturing process, we will transform client plasmid into a production host. We create a glycerol stock cell bank using “low metabolic burden technology”; this cell bank is maintained at NTC at no additional fee for additional future orders of the same plasmid.
The REVIVER™ host strains are engineered specifically for stable, high quality production of ITR and large palindrome-containing plasmids.
The REVIVER™ is used for traditional plasmid vectors (e.g. pUC origin) and the REVIVER-NP is used with Nanoplasmid™ vectors.
DID YOU KNOW
The Nanoplasmid Enhances DNA Vaccines for Venezuelan Equine Encephalitis Virus and Ebola Virus
To find out more, read the article linked below.