Improved DNA manufacturing
NTC’s patented HyperGRO™ fermentation process and media has produced record pDNA yields of up to 3.5 g/L, and typically produce 0.5-1.5g/L using a high copy pUC, R6K, or similar origin, and a recA-, relA-, endA- host strain, such as DH5 alpha. Highly concentrated HyperGRO™ plasmid preparations naturally result in cleaner, more highly-purified DNA (due to dramatically reduced biomass), and more cost-effective production as well. more....
Viral Vector Retrofits
Including: AAV, Lenti, Retrovirus, Helper Vectors & Transposons
NTC’s "antibiotic free" Nanoplasmids™ are easily substituted for conventional plasmids, minicircles, doggy bones, etc., for use with all major therapeutic vector groups. The Nanoplasmid™ backbone has profound and unexpected beneficial effects on performance (expression levels and duration). The Nanoplasmid™ is now available for use in all major viral vector groups...more
Nanoplasmids™, Non-viral vectors
Improved in vivo expression, duration, safety, economy, and
ease of use.
The Nanoplasmid™ is a dramatically improved Key Cassette (<500 bp), designed to replace the antiquated bacterial backbones that have for decades been the industry standard in DNA vectors. It is perfect for gene and cell therapeutics, DNA vaccines, immunotherapeutics...more
Nature Technology (NTC) is a "one stop shop" for gene therapy industry partners, providing state of the art
Technologies and Services that are needed for success in the clinic, and beyond.
Biologics by design